Liquisolid Compacts: An Approach to Enhance the. Dissolution Rate of Nimesulide. Srinivas Vaskula, Sateesh Kumar Vemula, Vijaya Kumar. PDF | ABSTACT Liquisolid compacts were used to formulate water insoluble drugs in non volatile solvents and convert into acceptable flowing. PDF | The aim of this study was to investigate the use of liquisolid technique in improving the dissolution of Glimepiride in a solid dosage form. This study was.
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Formulations containing Fujicalin and Neusilin showed improved flowability in comparison to Avicel PH To calculate the required amounts of powder excipients including both carrier and coating materials a mathematical approach for the formulation of A powder may be able to retain only limited amounts of liquid while maintaining acceptable flow and compression properties.
The hardness of the tablets was determined using Monsanto hardness tester. It can be concluded from this study that novel porous carriers are superior to traditional carriers in liquisolid systems and are suitable for loading high dose drugs like CBZ.
As shown in Table liquidolidLSA 15 showed prompt drug release with value of This question is for testing whether you are a human visitor and to prevent automated spam submissions. The objective of the present investigation was to develop liquisolid compacts for olmesartan liquiso,id to improve the dissolution rate.
December 20, Published: This would explain the improved drug dissolution from liquisolid compared to conventional preparations. Guidelines Upcoming Special Issues.
Formulation and Evaluation of Liquisolid Compacts for Olmesartan Medoxomil
Therefore, it was essential to study the flowability of these liquisolid powder admixtures prior to compression. Ann Jose ankara escort.
This indicates that there is no interaction between the drug and excipients. The thermogram showed a sharp endothermic peak at of Most of hydrophobic drugs show very poor dissolution in the gastro intestinal tract, leading to erratic and incomplete drug absorption.
Solubility of CBZ was determined in different non volatile solvents to finalise vehicle having maximum solubility. Another measure of tablets strength is friability.
This could be probably due to the presence of higher amounts of silica in and lower in. Olmesartan appears to be more soluble in Acrysol EL than other vehicles.
To this liquid medication, the calculated amount of the carrier was added by continuous mixing in the mortar. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Permissions beyond the scope of this license may be available with editor ijper. View at Google Scholar I. The liquisolid technology is described by Spireas as liquid may be transformed liqulsolid a free-flowing, readily compressible, and apparently dry powder by simple physical blending with selected xompacts named the carrier and coating material Figure 1.
The liquisolid approach is a potential technology due to its simplified manufacturing method, cheaper production costs and the prospect of industrial scale up due to the good flow and compaction properties.
Liquisolid Compact Technique: A Novel Approach to Solubility Enhancement | OMICS International
Table of Contents Alerts. Olmesartan dose dependently reduces the blood pressure through arterial vasodilation and reduced sodium retention, as do other angiotensin receptor blockers [ 8 ]. Fujicalin Dibasic calcium phosphate anhydrous and Neusilin Magnesium aluminometasilicate were obtained as gift sample from Fuji Chemical Industry Co. December 19, Accepted: International Journal of Pharmaceutics As a most discussed but still not completely resolved issue, solubility or dissolution enhancement techniques remain the most vibrant field for the researchers in formulation science.
Liquisolid compacts were prepared using Acrysol Compxcts as a solvent, Avicel PHFujicalin and Neusilin as carrier materials, and Aerosil as coating material in different ratios. However, this technique cannot be applied to high dose poorly soluble drugs is because of the high amount of liquid vehicle needed.
Over past few decades, many techniques have been developed, to improve the solubility and dissolution of poorly soluble substances, with different degrees of success which includes micronization, lyohilization, solid dispersion, etc. Agri and Aquaculture Journals Dr. Angle of slide determination is an important step in the formulation of liquisolid tablets. Powder flowability is crucial in the industrial production luquisolid tablet dosage forms, as a uniform powder stream through hopper confirms uniformity of both tablet weight and drug content.
A lesser amount of Neusilin was required to adsorb the same amount of liquid vehicle than Avicel and Fujicalin, which lowered the weight of tablet. Cumulative percent drug release was plotted as a function of time, and percent drug release in 5 minutes was calculated. Inert, preferably water-miscible organic solvent systems with high boiling point and a not highly viscous organic solvent system such as propylene glycol, liquid polyethylene glycols, polysorbates, fixed oils, or glycerine are best suitable as liquid vehicles [ 5 ].
The highest liquid factor was obtained for Neusilin, and accordingly, the amount of carrier was lower than other formulations. Olmesartan medoxomil is an angiotensin type II receptor blocker, antihypertensive agent, administered orally.
International Journal of ChemTech Research 2: Six tablets from each formulation were tested for hardness. The appropriate amounts of carrier and coating materials used for each formulation depend upon of that formulation.
In the formulation development process solubility of active compound is one of the main criteria considered before deciding the dosage form.
Formulation and Evaluation of Carbamazepine Liquisolid Compacts Using Novel Carriers
Spireas S, Sadu S Enhancement of prednisolone dissolution properties using liquizolid compacts. For liquisolid mixture, the endothermic peak of the drug completely disappeared indicating that the drug is completely solubilized and molecularly dispersed with excipients within liquisolid system. From the dissolution profiles, it can be seen that all liquisolid formulations significantly improved drug dissolution compared to conventional tablets.
The was then liqisolid to decide the optimum amount of carrier and coating materials required to ensure dry-looking, free-flowing and compactible powdered systems.
Journal of Drug Delivery
Composition of liquids solid compacts batches is shown in Table 1. The and for liquid vehicles were used to calculate.
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