Substances Authority for information on how to prevent and detect abuse or diversion of this product. Interactions with other CNS Depressants. Medscape – Detoxification, pain-specific dosing for Methadose, Dolophine opioids; Substantial interpatient variability, see prescribing information for guidance. Find patient medical information for Dolophine Oral on WebMD including its uses , side effects and safety, interactions, pictures, warnings and user ratings.

Author: Vimuro Mikarisar
Country: Uganda
Language: English (Spanish)
Genre: Medical
Published (Last): 27 June 2007
Pages: 320
PDF File Size: 7.43 Mb
ePub File Size: 6.56 Mb
ISBN: 325-4-20091-591-3
Downloads: 7415
Price: Free* [*Free Regsitration Required]
Uploader: Kekazahn

The risk of addiction in any individual is unknown.

Patients with cancer-related pain may have decreased clearance of methadone as compared to patients with chronic, benign pain. If an opioid must be used, consider reducing use of other CNS-active medications that increase the risk of falls and fractures and implement other strategies to reduce fall risk.

Your Name Your name is required. Intravenous methadone should only be used on a temporary basis for patients who cannot take oral medication, such as hospitalized inpatients. A relapse to illicit drug use is a risk upon discontinuation. Opiate agonists can induce vasovagal syncope or orthostatic hypotension. Cases of serotonin syndrome, a potentially life-threatening condition, have been reported during concomitant use of methadone with many types of serotonergic drugs.

Serotonergic drugs include selective serotonin reuptake inhibitors SSRIsserotonin and norepinephrine reuptake inhibitors SNRIstricyclic antidepressants TCAsserotonin-receptor agonists “triptans”, 5-HT3 receptor antagonists, drugs that affect the serotonergic neurotransmitter system e. With long-term methadone therapy for opiate addiction, nearly complete tolerance develops to any analgesic effects of the medication.


The growth deficit does not appear to persist into later childhood. Avoid use of partial agonists precribing. It is not known whether the effects on fertility are reversible.

Methadone Dolophine, Methadose – Treatment – Hepatitis C Online

Prdscribing shall not exceed 21 days or be repeated earlier than 4 weeks after completion of a preceding course. Monitor patients for hypotension at the initiation of therapy and during dose titration.

Inject into a large muscle mass. Monitor patients frequently for CNS and respiratory depression, particularly during the first 24 to 72 hours after initiation or dose escalation.

The absorption of subcutaneous SC methadone has not been well characterized and prfscribing to be unpredictable. For the treatment of moderate to severe pain not responsive to non-narcotic analgesics. Extreme caution should also be used in patients with informatioj asthma, kyphoscoliosis a type of scoliosishypoxemia, or paralysis of the phrenic nerve. Continue as long as desired by the patient and continued benefit is derived; maintenance programs are effective retaining patients in treatment and suppressing opiate use.

In most samples, the milk concentrations were lower than maternal serum drug concentrations at steady state. Women maintained on methadone require appropriate prfscribing pain management, as methadone maintenance does not provide analgesia.

Use with caution in patients with GI disease including GI obstruction, ulcerative colitis, or pre-existing constipation.

PDR Search

Methadone may significantly decrease respiratory drive and cause hypoventilation. BOXED WARNING Angina, bradycardia, cardiac arrhythmias, cardiac disease, coronary artery disease, diabetes mellitus, females, heart failure, hypertension, hypocalcemia, hypokalemia, hypomagnesemia, hypotension, hypovolemia, long QT syndrome, malnutrition, myocardial infarction, orthostatic hypotension, QT prolongation, thyroid disease.

Geriatric or debilitated patients are more susceptible to adverse reactions, especially sedation and respiratory depression, probably as a result of altered distribution of the drug or decreased elimination. Biliary tract disease, constipation, diarrhea, GI disease, GI obstruction, ileus, inflammatory bowel disease, pancreatitis, ulcerative colitis.


Respiratory depression, if left untreated, may cause respiratory arrest and death. Methadone should be reserved for patients in whom alternative treatment options e. It is important to note respiratory depressant effects occur later and persist longer than peak analgesic effects.

Methadone infogmation not recommended for analgesia during labor and obstetric delivery due to its long duration of action and potential for respiratory depression in the newborn. In opioid-tolerant patients, convert the current total daily dose of all opioids to an oral morphine equivalent dose, then multiply the morphine equivalent dose by the corresponding percentages in the dose conversion table provided in the FDA-approved labeling.

Use methadone for severe pain during pregnancy only if the potential benefit justifies the potential risk to the fetus. Insoluble excipients will be informatiin after tablets are dissolved; they will not completely dissolve.

Recipient’s Email Separate multiple email address with a comma Please enter valid email address Recipient’s email is required. Abuse and addiction are separate and distinct from physical dependence and tolerance; patients with addiction may not exhibit tolerance and symptoms of physical dependence.