ABSTRACT. The present study aimed to evaluate the in vitro antimicrobial activity of pharmacologically important Adhatoda vasica plant extracts. Plant Adhatoda vasica L. Nees (Acanthaceae) commonly known as Malabar nut is an evergreen two – three m tall shrub, sometime used as. Adhatoda vasica (L.) (Acanthaceae) is used in the indigenous system of medicine in India. The alkaloid Vasicine was isolated from ethanolic extract of the .

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The structure was elucidated using spectroscopic methods: Cytotoxicity of each sample was expressed as IC 50 value. The plant is used in the indigenous system of medicine in India and is a atnimicrobial expectorant in both Ayurvedic and Adhafoda Systems of Medicine [ 45 ].

Antifeedant and toxic activity of Adhatoda vasica leaf extract against Spodoptera littoralis Lep. Vasicine acetate was obtained by acetylation of Vasicine. Introduction Natural products still remain the most important source for discovery of new and potential drug molecules.


Every year, at leastpeople activoty worldwide from cancer related to their workplace [ 3 ]. The crude extract of A.

The combined chloroform extract was washed with water, dipped, and dried over anhydrous sodium sulphate.

Indian Journal of Microbiology. Other constituents include vitamin C, saponins, flavonoids as well as steroids, and fatty acids [ 13 ].

Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Table 2 Minimum inhibitory concentration of Vasicine acetate against tested bacteria and fungi. Vasicine acetate could be probed further in drug discovery programme.

It was then distilled on a water bath and the residue was washed with little n-hexane. Vasicine showed antimicrobial activity against S. It was studied for antimicrobial, antioxidant, and anticancer activities.

Nature acts as a prominent reservoir for new and novel therapeutics. The fraction was further purified and the compound Vasicine was isolated.

Streptomycin was used as positive control for bacteria and Ketoconazole as positive control for fungi.

Antibacterial Activity of Leaf Extracts of Adhatoda vasica – MAHE Digital Repository

Glossary of Indian Medicinal Plants. Indian Journal of Medical Research. The estimation of Vasicine acetate content in the extract was performed using linear regression analysis.


Ray of hope for cancer patients. Nees Acanthaceaeknown commonly as Malabar nut tree, is a shrub growing throughout the Indian peninsula.

Sample ethanol extract Microbial Organisms The following Gram negative, Gram positive bacteria, clinical isolates, and fungi were used for the experiment: Accumulation of vasicine and vasicinone in tissue cultures of Adhatoda vasica and evaluation of the free radical-scavenging activities of the various crude extracts.

The plant was identified by Dr. Materials and Methods 2. In the present communication we report the antimicrobial, antioxidant, and anticancer effects of Vasicine acetate acetylated from Vasicine obtained from A.

Mobile phase A consisted of water with 0. The spot turned orange red on spraying with Dragendorff’s reagent. Shade dried and coarsely powdered leaves of A. A human adenocarcinoma cancer cell line was obtained from National Institute of Cell Sciences, Pune. Vasicine acetate showed antimycobacterial activity [ 15 ].