Substances Authority for information on how to prevent and detect abuse or diversion of this product. Interactions with other CNS Depressants. Medscape – Detoxification, pain-specific dosing for Methadose, Dolophine opioids; Substantial interpatient variability, see prescribing information for guidance. Find patient medical information for Dolophine Oral on WebMD including its uses , side effects and safety, interactions, pictures, warnings and user ratings.

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Use methadone with caution in patients with adrenal insufficiency i. This syndrome can be life-threatening.

Reserve concomitant use of these drugs for patients in whom alternative treatment options are inadequate. Serotonergic drugs include selective serotonin reuptake inhibitors SSRIsserotonin and norepinephrine reuptake inhibitors SNRIstricyclic antidepressants TCAsserotonin-receptor agonists “triptans”, 5-HT3 receptor antagonists, drugs that affect the serotonergic neurotransmitter system e.

Onset, duration, and severity of opioid withdrawal may vary based on the specific opioid used, duration of use, timing and amount of last maternal use, iinformation rate of elimination by the newborn. Administer prescribung every 6 to 8 hours. Drugs known to prolong the QT presceibing, potentiate hypokalemia, or reduce methadone elimination should be coadministered with a careful assessment of risks versus benefits.

Other opioids may be tried; some cases reported use of a different opioid with no recurrence of adrenocortical insufficiency.

Methadone Dolophine, Methadose – Treatment – Hepatitis C Online

Because concentrates may numb the mouth or upset the stomach, it may be preferable to mix in 3—4 ounces 90— ml of liquid e. Advise breast-feeding women taking methadone to monitor the infant for increased drowsiness and breathing difficulty.


Medical withdrawal from methadone dolophune be done in decrements as tolerated by the patient on a daily basis or at 2-day intervals.

Avoid use of partial agonists e. Local tissue reactions may occur with IM use. Although true opiate agonist hypersensitivity is rare, patients who have demonstrated a prior hypersensitivity reaction dolophinw not receive methadone.

FDA-approved labeling recommends an initial 2: Withdrawal of methadone following detoxification treatment. Methadone has not been extensively evaluated in patients with renal insufficiency.

Additional doses of 5 to 10 mg of methadone PO may be given 2 to 4 hours after the initial dose if withdrawal symptoms have not been suppressed or if symptoms reappear.

Insoluble excipients will be present after tablets are dissolved; they will not completely dissolve.

Patients with chronic liver disease may require less frequent dosing intervals. All forms of methadone have the potential for overdose or poisoning. Stir well and have patient drink all of the dosage dispersed. prescribig

BOXED WARNING Angina, bradycardia, cardiac arrhythmias, cardiac disease, coronary artery disease, diabetes mellitus, females, heart failure, hypertension, hypocalcemia, hypokalemia, hypomagnesemia, hypotension, hypovolemia, long QT syndrome, malnutrition, myocardial infarction, orthostatic hypotension, QT prolongation, thyroid disease. No increased risk of miscarriage in the second trimester or premature delivery in the third trimester was noted by a retrospective review of data from opioid-dependent women.


Initially, use a 2: Discontinue all other around-the-clock opioid drugs upon initiation of methadone.

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Administer dosage every 8 to 12 hours. Avoid use in patients with impaired consciousness or coma. Opiate agonists may obscure the diagnosis or clinical course in patients with acute abdominal conditions. Asthma, chronic obstructive pulmonary disease COPDcoadministration with other CNS depressants, cor pulmonale, hypoxemia, obesity, pulmonary disease, respiratory depression, respiratory insufficiency, scoliosis, sleep apnea, status asthmaticus.

Initial doses may need to be reduced, and doses should be carefully titrated taking into account analgesic effects, adverse reactions, and concomitant drugs that may depress respiration.

Biliary tract disease, constipation, diarrhea, GI disease, GI obstruction, ileus, inflammatory bowel disease, pancreatitis, ulcerative colitis. Addiction may occur in patients who obtain methadone illicitly or in those appropriately prescribed the drug.

Use methadone with caution in patients with cardiac disease or other conditions that may increase the risk of QT prolongation including heart failure, bradycardia, myocardial infarction, hypertension, coronary artery disease, hypocalcemia, or in patients receiving medications known to cause electrolyte imbalances. Due to the absence of data regarding methadone use in patients with renal impairment, caution is recommended. Avoid abrupt discontinuation due to the potential prescrubing opioid withdrawal symptoms and relapse of addiction.