In cases of acute intoxication with propane butane (due to damage in heating appliances where propane-butane is used as energy source for heating), asphyxia. Butane is an organic compound with the formula C4H10 that is an alkane with four carbon . It enters the blood supply and within seconds produces intoxication. Butane is the most commonly misused volatile substance in the UK, and was the. Butane is a commonly misused volatile agent, and a cause of intoxication. We present a case, who had a syncope and persistent ventricular.
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BH 3 special conditionscovalent metalloid hydride Right: Further, a larger factor would lead to unrealistically low values that would be similar vutane the AEGL-2 values. Butane appears to be negative in the Ames test, with and without metabolic activation citation of an unpublished report in Moore Although case reports of butane exposure indicate potential aau cardiac sensitization analogous to propanethis end point has not been studied.
She was found unconscious and required mechanical ventilation for 5 h. An electrocardiogram showed an acute anterolateral infarction. Further, no noticeable irritation was reported at concentration up toppm for a short exposure duration exact duration unknown. Metabolism and Disposition 4. For similar reasons and because subjects exposed at slowly increasing concentrations of butane up to 50, ppm for at least 10 min did not experience any significant adverse effects, a modifying factor is not considered necessary.
However, the effects are not disabling and are transient and reversible upon cessation of exposure. Six dogs were exposed to butane for various durations to study its potency as a cardiac sensitizer Chenoweth Other dogs showed no ventricular fibrillation after injection with epinephrine intoxciation exposed to butane at about 50, ppm. Concerned parents Children affected by a intoxicztion drinking Alcohol and Cancer Worried about someone? The effects are attributed to butane itself and no relevant differences in kinetics are assumed, so only small interindividual differences are expected.
Retrieved 3 October Huge exposure concentrations can be assumed in butane abuse.
Butane intoxication–three case reports.
National Center for Biotechnology InformationU. Severe encephalopathy was observed in a year-old girl as the result of butane abuse. Lithium hydride, LiH ionic metal hydride Beryllium hydride Left gas phase: The concentration-response curve appears to be very steep indicating that a large uncertainty factor is unnecessary. The exposure duration and concentration of butane were not reported, nor was the amount of time that elapsed before resuscitation commenced.
Light anesthesia was defined as being unable to maintain an upright position in a rotating bottle 2 mice in a 2-L bottle. View in own window. It enters the blood supply and within seconds produces intoxication. Third, the use of an intraspecies factor of 3 would lead to AEGL-1 values that are unrealistically low e. Groups of mice sex and strain not specified were exposed to butane at concentrations of , , , orppm; 6 mice were tested at the lowest concentration and 10 mice at each of the higher concentrations Stoughton and Lamson Light anesthesia can be considered serious enough to impair escape, and could be used as basis for AEGL Normal butane can be used for gasoline blending, as a fuel gas, fragrance extraction solvent, either alone or in a mixture with propaneand as a feedstock for the manufacture of ethylene and butadienea key ingredient of synthetic rubber.
It was concluded that 10, ppm min exposure was a boundary for drowsiness.
Butane intoxication–three case reports.
Related articles Butane cardiac arrest hypoxic encephalopathy industrial gas intoxication. Consequently, these values were selected as the reasonable lower and intoxicatjon bounds of n to use when data are not available to derive an empirical value for n.
Three cases of sudden death due to butane or propane gas inhalation: Butane is a colorless gas with a faint disagreeable odor, although it is considered to be odorless by some. Although case reports indicate that butane might cause arrhythmias in humans exposed at high concentrations, no adequate human or animal data are available to evaluate this end point in a quantitative way.
Cardiac arrest following butane inhalation Sen A, Erdivanli B – Anesth Essays Res
American Journal kntoxication Applied Sciences. These data are only briefly described because they provide no clear dose-response data and, for abuse cases, subjects generally have a history of repeated exposure, so tolerance to butane could have developed Evans and Raistrick Forensic medical evaluation of deaths resulting from inhalation of cigarette lighter refill fuel in Turkey. Dogs were artificially ventilated via an endotracheal cannula and several parameters of cardiac function e. Repeated magnetic-resonance-imaging scans revealed disintegration of gray matter, increasing cerebral atrophy, and destruction of basal ganglia.
The 2-h lethality data in mice obtained by Stoughton and Lamson were remarkably similar to those obtained butanr Shugaev Light and complete anesthesia occurred in mice exposed to initial concentrations of butane atppm within 25 min andppm within 15 min. It is poorly soluble in water. The concentration-response curve appears to be very steep indicating that a large factor s unnecessary.
The system operating pressure for butane is lower than for the halomethanes, such as Rso R systems such as in automotive air conditioning systems, when converted to pure butane will not function optimally and therefore a mix of isobutane and propane is used to give cooling system performance comparable to R Neurotoxicity No data other than that described in Sections 3.
Intoxlcation might be explained by the difference in the ratio of minute ventilation to body weight, which is approximately two-fold greater in mice. A summary of nonlethal effects from acute inhalation of butane is provided in Table